Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells

 Notícias
Dec 042019
 

Olá,

O artigo do Júnior acaba de aparecer como HOT articles no RSC Advances:

Graphical abstract: Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells

José C. Quilles Junior, Fernanda dos Reis Rocho Carlos, A. Montanari, Andrei Leitão, Viviane W. Mignone, Maria Augusta Arruda, Lyudmila Turyanska and Tracey D. Bradshaw

Novel apoferritin encapsulated cysteine protease inhibitors are developed with enhanced and selective uptake by cancer cells, and sustained pH-induced release of the agent. The persistent inhibition of cathepsin L is demonstrated in vitro.

From the themed collection: RSC Advances HOT Article Collection
The article was first published on 11 Nov 2019
RSC Adv., 2019,9, 36699-36706
https://doi.org/10.1039/C9RA07161J

Obrigado à CAPES/Drug Discovery pelo apoio.

Obrigado também à FAPESP que possibilitou a síntese dos compostos estudados.

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